Omega-3 fatty acids (Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA)) which found in fish oil have been widely recognized due to their beneficial effects on health, and are considered as essential supplements in human food. The present study elucidated the therapeutic effect of omega 3 fatty acids on the liver and kidney functions in hyperlipidemic and hypothyroid albino rats. The current results showed that the liver function parameters were affected by hyperlipidemia which recorded marked improvement after fish oil administration; however, their showed non-significant changes by hypothyroidism. Additionally, serum creatinine and uric acid concentrations were increased significantly while urea level showed non-significant change in the hyperlipidemic and hypothyroid groups. Furthermore, fish oil administration improved the kidney function parameters in both groups. fish oil supplementation showed benefit effects on the liver and kidney functions in both hyperlipidemic and hypothyroid groups which may be due to the beneficial effects of omega-3 fatty acids.
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