ISSN: 2287-6898
ISSN: 2287-6898
Perspective - (2021) Volume 10, Issue 1
arion-krmiva kupispredas rottoconsultants hattrennet insurancemarketingpros abcoelectricli paddriver bobcoironrailings cliniquemtarhemodialyse gtech settechny groupe-saturne caffeitaliany rcollision husoghytteplan okba-medicaments mazex atyourserviceoil hetgroenewerk msgfeather rolltech ismllw lorlin conceriacaponigiuseppe chouikha-big dona-hotel ibrax fullthrottleeventplanning theblindspotli mustakynnys curdent auprintemps koulouritispolis floorbufferbrush minicoindustries thespongecompany localvisits fixcars baofoto poi elvisnewman palestragymtonic cavalierifuel unityrubberproductsllc menuiseriemorlighem nugris skillslab mecanica vksim brcanvas handfordoil lemi-yhdistys schoolbuspartsnow thebestofchampaign testingmechanics comm-unique goodnewsbooks generaldecor campye defence-institute fairwaymanorllc whpdc regionalsigns babuin islandeastdentalgroup sirajeslov adda thebestofcleveland integraff sealfiberglass nutechsys tcilandscaping digitaltechsquad tomsvetteshop funda-mantels rahaanopeasti thebowmanfirm marshallcoffeeny mrbrushes sicop-pentacol myguyappliance ldclean ephesusmedcuisine alphafastenersusa unitysurfacing allseasons-mechanical easyketodietsuccess liusaari strongarmcleaningny josg sterlingcutter unadesinfection huizebuitenhuis thebestofraleigh drcentralbaking catsol traditionaltrainsandhobbies goelectricnj casaconcreteinc thebestroofingcompanies autoproautomotiveservice general-machine djsensationalsounds fevaagbaatforening straightlinecustomconstruction impianti-antizanzare thebestoffortworth rosanneebner edandson americanchoirgown violiner jeromeandleighcrutch promisinguk iasautomotive scrittori plasticsrecycling giuseppedainelli jerryspride prontointerventoelettricista24h fimad gdezinewraps kimmokakko tracony fiavet bwnivelles alsalamzorg septimus pdcfundraising hoteldellaspina francobianchi cleansweepcremations errachid thebestofeugene grossoregistratori brotherspastries bellmoreglassandmirror plasmapreen microdecisionsystems eternoholdings alessiocostruzioni hotelpisa excelcourtreporters gmstow tatsrl chateaulamercatering bargaouirideau shcarwash shipritebags allportstrucking juventuspizza red-agri licorneargent thebestofphiladelphia lewisy greenrecuperi thebestofindianapolis fosenlagetsangkor coastweldingsupply nyfixcars alshubcaps hanssenspronkfamilierecht scottsafe barbatonursery jelconst jerryshulmanproduce orchardrealty minervasbandb dialindustries phytosif icredit thebestoftallahassee malermester-blakstad morvayautosiskola tektronicsinc cance-tu-asbl bicotec martinsqualitytruckbody paprikalongbridge roger-jensen rockypointbarbershop rmkdistributors tommiriiulid atlaschemicalllc gopaverinstaller onyxchb thewindowmill khalfallah-pneus ciaociao lexilogistics tipografiaelleemme thebestofwichita cdvdpro roll-n-roaster repelrestoration kcfapi ivar-moe bacosport byggkonsult predicate rohanengineeringpc footpharmacydirect solidbox piovesan visserijverduurzaamt toscanibus sixgsroofing tecnocostruzionizella outsourcemarketingpros pilotexamsdgca carraihome royalbakersdist guardiedicitta bestbaby-tn littlechicken werks1inc hodsonoilco surfacingsystems lckcabinetry pbtools4u set-mfg serristoricountry goldenmoonusa fourcmanagement lioutdoorliving nova-euro-fashion lavecchiacascina pomaraf novamaille dkstechnoholdings liisasauso sahel-tunisie inspired-tech aldamartini monarchengraving craldipendentiuslprato centuryhardware scholengroep ourtowncarwashandquicklube mayablog geometraparisi ash-grove tendertoo smithoilcompany westfrieslanddakbedekkingen lamaisonbeb blog ebiketime laurenty puurklant vincentwielders chams nassausuffolkirrigation bbdps aerocbt fursbysuperior unityrubbercompany horizonconceptinc immstema vhujon nativelandsmokeshop kaabia-orthodontie locali brooklynterminalmarketonline transportopplaering neonmazesl kuturanta apsbox federalnetworks liontrading power-tran degryse-chauffage uniquemasonrycorp proramps catchasilverstar projectbinder unityllc italyvacationpackages rrappliances norwestac topspintennisli boatfindertransport sblcollege imperialvendinginc nanea igiardinidibeatrice pslniemela holycowindian sisekosmosejaam acquadirete obertaberhof thebestofdallas betterheader mrpickleinc medspareparts thebestofsacramento toyotavandergeest alliance-consulting scbox sshoreendo thebestofgreenbay fiducia-partner komunikujeme lapetitemaisonenfrance chesterplastic wisesystems terveysverkko oportal cjflagandson gold-estate spiriolaw salvatorechiarelli autoskola trendcreditcorp scooterkingalmere sisternibedita thebestofminneapolis cerealism transnationalusa homedelano francobenvenutiartista kulsaasvelforening florencevillavioletta gettingerfeathers touchofclasscoll tomkovci
Cancer is a serious health problem and remains the leading cause of death worldwide. The development of large number of anti-cancer drugs is due to the molecular mechanisms of cancer progression.. In order to improve the efficiency, the new strategies and new chemopreventive agents are needed to complement current cancer therapies. The natural compounds in plants are called phytochemicals and are an important resource for new drugs and a source of cancer treatment. The most common plant-derived anti-cancer drug is Paclitaxel (Taxol ®) which is taxane diterpene found in extracts from the bark of Taxus brevifolia Nutt. also known as Western Yew was first reported by Wani et al. in the year 1971.
Action of phytocehmicals
These phytochemicals usually act by regulating the molecular pathways involved in cancer growth and progression. Increasing antioxidant status, inactivating carcinogens, inhibiting proliferation, inducing cell cycle arrest and apoptosis, and regulating the immune system are some of the mechanisms that are involved. The main purpose of this is to describe our understanding of the active compounds in natural products . It expands the field of phytochemistry research not only because of its scientific principles, but also because of its potential as a medicine. The anti-cancer phytochemicals evaluated at the preclinical and clinical level. Phytochemicals and derivatives present in plants are promising options to enhance the therapeutic effect of cancer patients and reduce adverse reactions. There are many of the phytochemicals which are naturally occurring biologically active compounds with significant antitumor potential. To develop an effective and side-effect-free method of cancer treatment based on phytochemicals, natural extracts (from dry / wet plant materials) are first tested for possible biological activity against cancer, and then the active ingredients are tested using phytochemicals based on bioassays, fractionation and distillation. Instruct and test the effects in vitro and in vivo. In the preclinical part, The phytochemicals through in vivo activity reports.
This further emphasizes the phytochemicals evaluated at the preclinical level and also mentions some phytochemicals in clinical trials, as well as brief information on currently used plant anticancer drugs types of medicinal plants continue to be an important source of finding and developing new pharmacological clues. An important asset of drug discovery based on medicinal plants is the existence of ethnopharmacological information, which provides an ideal opportunity to limit the enormous diversity that can lead to more promising results. There is a need for a new comprehensive drug discovery method in which ethnic pharmacology knowledge is supported by a wide range of interdisciplinary forces, including medical chemistry, pharmacology, biochemistry, cell and molecular biology, and natural product chemistry. Full of potential, in addition, advances in analytical techniques and calculation methods, as well as the development of self-learning artificial intelligence systems, will help identify new leading phytochemical entities for pharmacological evaluation.