Hypoglycemic activity of Psoralea glandulosaon streptozotocininduced diabetic rats

Abstract

Author(s): Kotresha D, Sandhya D and Prakash T

Psoralea glandulosais one of the important medicinal plant, used as a medicine for antibacterial, antifungal, antihyperlipemic, anti-inflammatory, antimutagenic, antioxidant, antipsoriatic, antitumorous, antiviral, cytotoxic, febrifuge. Preliminary phytochemical investigation of petroleum ether, chloroform and ethanolic extracts of leaves of P. glandulosashowed that it contains fixed oil, glycosides (saponin glycosides), alkaloids and carbohydrates. Ethanolic extract of P. glandulosaleaves was found to be effective. The supplementation of ethanolic extract (250 and 500 mg/ kg) of P. glandulosaleaves improved the glucose tolerance in the fasted normal rats. Ethanolic extracts (250 and 500 mg/kg) and Glibenclamide treated groups shows significantly prevented reduction in the body weight. Biochemical parameters such as urea, cholesterol, triglyceride, protein, liver glycogen estimated and ethanolic extracts (250 and 500 mg/kg) of P. glandulosafasted group showed all most equal to normal group. Ethanolic extract of P. glandulosaleaves showed potential anti-diabetic action in streptozotocin induced diabetic rats. Probably due to the presence of more than one anti-hyperglycemic principle and their synergistic properties and due to its antioxidant activity since one of the proposed mechanismsof diabetic effect of streptozotocin through generationof free radicals