Enhancement of Dissolution Rate of Cefixime Trihydrate by Using Various Solid Dispersion Techniques

Abstract

Author(s): Prasanna SRV* and Sunil Babu Koppula

Solid dispersion was introduced in the early 1970s , refers to a group of solid products consisting ofat least two different components, generally a hydrophilic matrix and a hydrophobic drug. There are different approaches which can be used for increasing the dissolution of the poorly soluble drugs. The development of solid dispersions as a practically viable method to enhance bioavailability of poorly water-soluble drugs overcame the limitations of previous approaches such as salt formation, solubilization by co solvents, and particle size reduction. The solubility of Cefixime Trihydrate is- soluble in methanol but insoluble in water. Cefixime Trihydrate is absorbed orally as 40 – 50% and 50% excreted unchanged in Urine because of poor solubility of Cefixime Trihydrate it is prepared as sold dispersions by using various techniques like Physical mixing, Co – grinding method , kneading technique and solvent evaporation technique. The main objective is to formulate a drug product as immediate release oral solid dosage form of Cefixime Trihydrate solid dispersion system which is considered to be stable, robust quality and enhanced dissolution rate. Thus kinetic study and dissolution study of the Formulated solid dispersions among the four different techniques used for preparation of solid dispersions solvent evaporation technique has shown the increase in dissolution rate that is the Trail-5 was found to have afaster solubility and dissolution property which was prepared by using Croscarmellose sodium as a disintegrant in the ratio of 1:1.Thus by this we can overcome the poor solubility drawback of the drug Cefixime Trihydrate.

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