Anti-Diabetic Activity of Ethanolic Extract of Nerium Oleander Flowers in Alloxan Induced Diabetic Rats

Abstract

Author(s): Swathi K.* and Ravi Shankar K

The present study was aimed to evaluate the anti-diabetic activity of ethanolic flower extract of Nerium oleander. Hypoglycemic activity was carried on normal rats and antidiabetic activity on alloxan induced diabetic rats. The experimental group was rendered diabetic by I.P injection single dose of 150 mg/kg Alloxan monohydrate. Diabetic rats were initially treated orally with ethanolic flower extract of Nerium oleanderat low dose of 200mg/kg and at high dose of 400 mg/kg and then compared with standard drug Glibenclamide at dose of 500μg/kg. Acute study for one day (0thhr, 1sthr, 2ndhr, 4thhr, 6thhr, 8thhr) and chronic study for 14 days (0thday, 7thday & 14thday) was carried out on alloxan induced diabetic rats using ethanolic flower extract of Nerium oleander. The effects of ethanolic flower extract of Nerium oleanderon body weights in rats was also observed in chronic study. Lipid profile and biochemical parameters were evaluated.These results suggest that Nerium oleanderhas a beneficial effect on diabetes